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JNJ10191584

CAT: 0804-HY-123532-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123532-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNJ10191584 (VUF6002) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM. JNJ10191584 shows 540-fold selectivity to H4 receptor over H3 receptor with a Ki value of 14.1 μM. JNJ10191584 inhibits chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively[1][2].
CAS Number
73903-17-0
Product Name Alternative
VUF6002
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jnj10191584.html
Purity
99.95
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(CC1)C)C2=NC3=CC(Cl)=CC=C3N2
Molecular Formula
C13H15ClN4O
Molecular Weight
278.74
References & Citations
[1]Venable JD, et al. Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h (4) antagonists. J Med Chem. 2005 Dec 29;48 (26) :8289-98.|[2]Sanna MD, et al. Histamine H4 receptor stimulation in the locus coeruleus attenuates neuropathic pain by promoting the coeruleospinal noradrenergic inhibitory pathway. Eur J Pharmacol. 2020 Feb 5;868:172859.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor; H4 Receptor

Alternative Products

CatalogName
BA5426-50JNJ10191584
H4R-AG-01Histamine receptor 4 (H4R) antagonist (JNJ10191584 maleate)

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