5-O-Demethylnobiletin (Standard)

5-O-Demethylnobiletin (Standard)

• CAS Number: 2174-59-6
• UNSPSC Description: 5-O-Demethylnobiletin (Standard) is the analytical standard of 5-O-Demethylnobiletin. This product is intended for research and analytical applications. 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].
• Target Antigen: Leukotriene Receptor; Lipoxygenase
• Type: Reference Standards
• Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease
• Field of Research: Inflammation/Immunology; Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/5-o-demethylnobiletin-standard.html
• Smiles: O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(O)=C13
• Molecular Weight: 388.37
• References & Citations: [1]Bas E, et al. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006 Feb;72(2):136-42.|[2]Chiu SP, et al. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013 Oct 2;61(39):9453-63.
• Shipping Conditions: Room temperature