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H2L 5765834

CAT: 0804-HY-15706-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15706-01Size:1 mg
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Description
H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively[1].
CAS Number
420841-84-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/h2l-5765834.html
Concentration
10mM
Purity
98.66
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(C(N(C3=CC=CC(OC4=CC=C([N+]([O-])=O)C=C4)=C3)C2=O)=O)C=C1)O
Molecular Formula
C21H12N2O7
Molecular Weight
404.33
Precautions
H302, H315, H319
References & Citations
[1]Williams JR, et, al. Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 2009 Jun 19; 284 (25) : 17304-19.|[2]Bae GH, et, al. Lysophosphatidic acid protects against acetaminophen-induced acute liver injury. Exp Mol Med. 2017 Dec 8; 49 (12) : e407.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LPAR1; LPAR3; LPAR5

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