Eldecalcitol (Standard)

• Description:

  Eldecalcitol (Standard) is the analytical standard of Eldecalcitol. This product is intended for research and analytical applications. Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1[1][2][3][4].

• Product Name Alternative:

  ED-71 (Standard) ; 2- (3-hydroxypropoxy) -1,25-dihydroxyvitamin D3 (Standard)

• UNSPSC:

  12352211

• Target:

  Apoptosis; Reference Standards; VD/VDR

• Type:

  Reference Standards

• Related Pathways:

  Apoptosis; Others; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer; Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/eldecalcitol-standard.html

• Smiles:

  O[C@H]1[C@@H](OCCCO)[C@H](O)C(/C(C1)=C\C=C2[C@]3([H])CC[C@H]([C@H](C)CCCC(C)(O)C)[C@@]3(C)CCC\2)=C

• Molecular Formula:

  C30H50O5

• Molecular Weight:

  490.72

• References & Citations:

  [1]Matsumoto T.Osteoporosis Treatment by a New Active Vitamin D3 Compound, Eldecalcitol, in Japan.Curr Osteoporos Rep. 2012 Aug 24.|[2]Huang C, et al. Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway. Drug Des Devel Ther. 2020 Nov 13;14:4901-4913.|[3]Lu Y, et al. Eldecalcitol inhibits the progression of oral cancer by suppressing the expression of GPx-1. Oral Dis. 2021 Aug 24. |[4]Saito H, et al. Eldecalcitol and calcitriol stimulates 'bone minimodeling, ' focal bone formation without prior bone resorption, in rat trabecular bone. J Steroid Biochem Mol Biol. 2013 Jul;136:178-82.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [104121-92-8]