Sugiol

• Description:

  Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS) -stimulated macrophages[1].

• Product Name Alternative:

  (+) -Sugiol; 10-Deoxoxanthoperol

• UNSPSC:

  12352005

• Target:

  ERK; Interleukin Related; JNK; p38 MAPK; TNF Receptor

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/sugiol.html

• Purity:

  99.88

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C(C=C(O)C(C(C)C)=C2)[C@@]3(C)CCCC(C)(C)[C@]3([H])C1

• Molecular Formula:

  C20H28O2

• Molecular Weight:

  300.44

• References & Citations:

  [1]Chao KP, et al. Anti-inflammatory activity of sugiol, a diterpene isolated from Calocedrus formosana bark. Planta Med. 2005 Apr;71 (4) :300-5.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  ERK1; ERK2; IL-1; JNK1; JNK2; p38 MAPK

• CAS Number:

  [511-05-7]