Avermectin B1a

Avermectin B1a

• CAS Number: 65195-55-3
• UNSPSC Description: Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.
• Target Antigen: Antibiotic; Parasite
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/Avermectin-B1a.html
• Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: C[C@@H](CC)[C@]1([H])[C@@H](C)C=C[C@@]2(O[C@@]3([H])C[C@]([H])(OC([C@@]4([H])[C@@](/C(CO5)=C/C=C/[C@H](C)[C@H](O[C@@]6([H])C[C@H](OC)[C@@H](O[C@]7([H])O[C@@H](C)[C@H](O)[C@@H](OC)C7)[C@H](C)O6)/C(C)=C/C3)(O)[C@@]5([H])[C@H](O)C(C)=C4)=O)C2)O1
• Molecular Weight: 873.08
• References & Citations: [1]Sun Y, et al. [Effects of avermectin B1a on soil microorganism and earthworm (Eisenia fetida)]. Ying Yong Sheng Tai Xue Bao. 2005 Nov;16(11):2140-3.|[2]Sun Y, et al. Bioaccumulation and elimination of avermectin B1a in the earthworms (Eisenia fetida). Chemosphere. 2005 Jul;60(5):699-704|[3]Huang J, et al. Avermectin B1a binds to high- and low-affinity sites with dual effects on the gamma-aminobutyric acid-gated chloride channel of cultured cerebellar granule neurons. J Pharmacol Exp Ther. 1997 Apr;281(1):261-6.|[4]Payne GT, et al. Activation of gamma-aminobutyric acid insensitive chloride channels in mouse brain synaptic vesicles by avermectin B1a.
 J Biochem Toxicol. 1991 Winter;6(4):283-92.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported