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Epacadostat

CAT: 0804-HY-15689-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15689-01Size:5 mg
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Description
Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM[1]. Epacadostat can effectively reduce Trp metabolism, entailing increased activation and maturation of dendritic cells, and enhanced proliferation of effector T cells and natural killer cells (NKs), as well as attenuated Tregs expansion.
CAS Number
1204669-58-8
Product Name Alternative
INCB 024360
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/INCB-024360.html
Concentration
10mM
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
BrC1=C(F)C=CC(N/C(C2=NON=C2NCCNS(N)(=O)=O)=N\O)=C1
Molecular Formula
C11H13BrFN7O4S
Molecular Weight
438.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Liu X, et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood. 2010 Apr 29;115 (17) :3520-30.|[2]Koblish HK, et al. Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors. Mol Cancer Ther. 2010 Feb;9 (2) :489-98.|[3]Fu R, et al. LW106, a novel indoleamine 2,3-dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma-immune crosstalk and cancer stem cell enrichment in tumour micro-environment. Br J Pharmacol. 2018 Jul;175 (14) :3034-3049.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
IDO1

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206461Epacadostat (INCB024360)

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