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PB94

CAT: 0804-HY-149766-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-149766-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PB94 is a selective HDAC11 inhibitor (IC50=108 nM) . PB94 can be radiolabeled as [11C]-PB94 for use in positron emission tomography (PET), as well as brain uptake and metabolic properties in administered live animals. PB94 improves neuropathic pain in mice and could be used to study neurological indications[1].
CAS Number
3032970-74-1
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pb94.html
Purity
97.04
Solubility
DMSO : 87.5 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C2C(C=CN2CC(C=C3)=CC(OC)=C3C(NO)=O)=C1)NCC4(C[C@@H](C5)C6)C[C@@H]6C[C@@H]5C4
Molecular Formula
C29H33N3O4
Molecular Weight
487.59
References & Citations
[1]Bai P et al. Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice. J Med Chem. 2023 Nov 16.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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