Tipepidine (hydrochloride)
CAT:
804-HY-121685A-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Tipepidine (hydrochloride)
- CAS Number: 1449686-84-3
- UNSPSC Description: Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron[1]. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect[2].
- Target Antigen: Potassium Channel
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/tipepidine-hydrochloride.html
- Purity: 99.92
- Solubility: DMSO : 41.67 mg/mL (ultrasonic)|H2O : 3.33 mg/mL (ultrasonic)
- Smiles: CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3.[H]Cl
- Molecular Weight: 311.89
- References & Citations: [1]Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current. Neuroscience. 2013 Nov 12;252:24-34.|[2]Kawaura K, et al. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Behav Brain Res. 2016 Apr 1;302:269-78.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched