5-Fluoro-5'-deoxycytidine-d3

• UNSPSC Description:

  5-Fluoro-5'-deoxycytidine-d3 is deuterated labeled 5-Fluoro-5'-deoxycytidine (HY-W009538). 5-Fluoro-5'-deoxycytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

• Target Antigen:

  Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Cell Cycle/DNA Damage;Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)C(F)=C2)=O)O[C@@H]1C([2H])([2H])[2H]

• Molecular Weight:

  248.23

• References & Citations:

  [1]Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported