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Pachypodol

CAT: 0804-HY-N3121-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3121-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pachypodol is an orally active methoxyflavonoid compound. Pachypodol activates the ERK-dependent Nrf2 pathway and inhibits Apoptosis. Pachypodol exhibits activities such as antioxidant, cytoprotective, anti-inflammatory effects. Pachypodol improves cognition. Pachypodol exerts protective effects against cardiac and liver damage. Pachypodol has anticancer activity against colon cancer[1][2][3][4][5].
CAS Number
33708-72-4
UNSPSC
12352005
Target
Apoptosis; Keap1-Nrf2; PERK
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pachypodol.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(OC)=C(C2=CC(OC)=C(O)C=C2)OC3=CC(OC)=CC(O)=C13
Molecular Formula
C18H16O7
Molecular Weight
344.32
References & Citations
[1]Kim EK, et al. Pachypodol, a Methoxyflavonoid Isolated from Pogostemon cablin Bentham Exerts Antioxidant and Cytoprotective Effects in HepG2 Cells: Possible Role of ERK-Dependent Nrf2 Activation. Int J Mol Sci. 2019;20 (17) :4082. Published 2019 Aug 21.|[2]Ali HA, et al. Pachypodol, a flavonol from the leaves of Calycopteris floribunda, inhibits the growth of CaCo 2 colon cancer cell line in vitro. Phytother Res. 2008;22 (12) :1684-1687. |[3]Zahara S S, et al. Pachypodol attenuates arsenic triggered cardiac damage via rectifying oxidative stress, inflammation, apoptosis and histopathological alterations. Journal of King Saud University-Science, 2024, 36 (7) : 103260.|[4]Zhang J, et al. Pachypodol protects newborn rats from anaesthesia-induced apoptosis in the developing brain by regulating the JNK/ERK pathway. Int J Dev Neurosci. 2021 Nov;81 (7) :633-642.|[5]Ijaz M U, et al. Pachypodol, a Plant Flavonoid, Mitigates Cisplatin-Induced Hepatotoxicity Through Anti-Oxidant, Anti-Inflammatory and Anti-Apoptotic Mechanisms. J. Food Nutr. Res., 2023, 11: 513-518.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
AB1932Pachypodol

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