GRGDSPK

• Description:

  GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD) . GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption[1][2].

• Product Name Alternative:

  EMD 56574

• UNSPSC:

  12352209

• Hazard Statement:

  H302-H315-H319

• Target:

  Integrin

• Type:

  Peptides

• Related Pathways:

  Cytoskeleton

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Metabolic Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/GRGDSPK.html

• Purity:

  98.12

• Solubility:

  H2O

• Smiles:

  O=C (N[C@@H] (CCCNC (N) =N) C (NCC (N[C@@H] (CC (O) =O) C (N[C@@H] (CO) C (N1[C@@H] (CCC1) C (N[C@@H] (CCCCN) C (O) =O) =O) =O) =O) =O) =O) CN

• Molecular Formula:

  C28H49N11O11

• Molecular Weight:

  715.76

• Precautions:

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations:

  [1]Sessions BR, et al. Effects of amino acid substitutions in and around the arginine-glycine-aspartic acid (RGD) sequence on fertilization and parthenogenetic development in mature bovine oocytes. Mol Reprod Dev. 2006 May;73 (5) :651-7.|[2]G A Gronowicz, et al. Synthetic Peptide Containing Arg-Gly-Asp Inhibits Bone Formation and Resorption in a Mineralizing Organ Culture System of Fetal Rat Parietal Bones. J Bone Miner Res. 1994 Feb;9 (2) :193-201.|[3]Pierre-Henri Puech, et al. Measuring Cell Adhesion Forces of Primary Gastrulating Cells From Zebrafish Using Atomic Force Microscopy. J Cell Sci. 2005 Sep 15;118 (Pt 18) :4199-206.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  111119-28-9