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Cinanserin

CAT: 0804-HY-133828Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-133828Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cinanserin (SQ 10643) is a potent and selective 5-HT2 antagonist with Ki values of 41, 3500 nM for 5-HT2, 5-HT1, respectively. Cinanserin also is a SARS-CoV 3CLpro inhibitor with an KD value of 49.4, 18.2 µM for SARS-CoV 3CLpro, HCoV-229E 3CLpro, respectively. Cinanserin reduces systemic burn edema levels[1][2][3].
CAS Number
1166-34-3
UNSPSC
12352005
Hazard Statement
H302
Target
5-HT Receptor; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cinanserin.html
Smiles
O=C(NC1=CC=CC=C1SCCCN(C)C)/C=C/C2=CC=CC=C2
Molecular Formula
C20H24N2OS
Molecular Weight
340.48
Precautions
P264-P270-P330-P501
References & Citations
[1]Hernekamp JF, et al. Cinanserin reduces plasma extravasation after burn plasma transfer in rats. Burns. 2013 Sep;39 (6) :1226-33. |[2]Chen L, et al. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J Virol. 2005 Jun;79 (11) :7095-103.|[3]Leysen, J. E., et al. Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors. Life Sciences, 1981, 28 (9), 1015-1022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MLAG-3; α-1 microglobulin

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