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Aaptamine

CAT: 0804-HY-N4225Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4225Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aaptamine is an alkaloid that can be isolated from the sponge Aaptos suberitoides. Aaptamine is a competitive antagonist of the α-adrenergic receptor, as well as an inhibitor of the proteasome and cholinesterase. Aaptamine is cytotoxic to tumor cells and can induce apoptosis, cell cycle arrest of tumor cells, and the expression of p21 through a p53-independent pathway. Aaptamine has multiple activities such as anti-tumor, antioxidant, antibacterial, and analgesic effects[1][2][3][4][5][6][7].
CAS Number
85547-22-4
UNSPSC
12352005
Target
Adrenergic Receptor; AP-1; Apoptosis; Bacterial; Cholinesterase (ChE) ; NF-κB; Proteasome
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Infection; Endocrinology; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aaptamine.html
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C2C3=C(N=CC=C3C=C1OC)C=CN2
Molecular Formula
C13H12N2O2
Molecular Weight
228.25
References & Citations
[1]Ohizumi Y, et al. Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle. J Pharm Pharmacol. 1984 Nov;36 (11) :785-6.|[2]Aoki S, et al. Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner. Biochem Biophys Res Commun. 2006 Mar 31;342 (1) :101-6.|[3]Tsukamoto S, et al. Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor. Bioorg Med Chem Lett. 2010 Jun 1;20 (11) :3341-3.|[4]Dyshlovoy SA, et al. Aaptamines from the marine sponge Aaptos sp. display anticancer activities in human cancer cell lines and modulate AP-1-, NF-κB-, and p53-dependent transcriptional activity in mouse JB6 Cl41 cells. Biomed Res Int. 2014;2014:469309.|[5]Suciati S, et al. In vitro and in silico cholinesterase inhibitory activities of aaptamine and derivatives from Aaptos suberitoides. Journal of Pharmacy and Pharmacognosy Research, 2025, 13 (3) : 757-773.|[6]Sung CS, et al. Antinociceptive Effects of Aaptamine, a Sponge Component, on Peripheral Neuropathy in Rats. Mar Drugs. 2023 Feb 4;21 (2) :113.|[7]Rajivgandhi G, et al. Marine sponge alkaloid aaptamine enhances the anti-bacterial and anti-cancer activity against ESBL producing Gram negative bacteria and HepG 2 human liver carcinoma cells. Biocatalysis and Agricultural Biotechnology, 2019, 17: 628-637.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE; BChE

Alternative Products

CatalogName
MBS5760099Aaptamine

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