Lumacaftor

Lumacaftor

• Product Name Alternative: VX-809; VRT 826809
• CAS Number: 936727-05-8
• UNSPSC Description: Lumacaftor (VX-809; VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.
• Target Antigen: Autophagy; CFTR
• Type: Reference compound
• Related Pathways: Autophagy;Membrane Transporter/Ion Channel
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/VX-809.html
• Purity: 99.85
• Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: FC1(F)OC(C=C(C=C2)C3(CC3)C(NC4=NC(C5=CC=CC(C(O)=O)=C5)=C(C=C4)C)=O)=C2O1
• Molecular Weight: 452.41
• References & Citations: [1]Van Goor F, et al. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18843-8.|[2]Phuan PW, et al. Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy. Mol Pharmacol. 2014 Jul;86(1):42-51.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched