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BRD8518

CAT: 0804-HY-161938Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-161938Size:1 Each
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Description
BRD8518 is a PCSK9 inhibitor (EC50=0.23 μM) . BRD8518 lowers blood lipids by upregulating LDLR expression and stimulating LDL uptake. BRD8518 can be used in the study of cardiovascular diseases[1].
CAS Number
[1565828-01-4]
UNSPSC
12352005
Target
LDLR; PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/brd8518.html
Smiles
O=C(NC1=CC=C2C(C(N(C)[C@H]3CC[C@@H](CC(NC4CC(C=CC=C5)=C5C4)=O)O[C@H]3CO2)=O)=C1)C6=CC=C(C(F)(F)F)C=C6
Molecular Formula
C33H32F3N3O5
Molecular Weight
607.62
References & Citations
[1]Xuhui Bao, et al. "Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) : from bench to bedside." Signal Transduction and Targeted Therapy 9.1 (2024) : 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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