Products for Research Use Only
RegisterLogin

Clobetasol propionate

CAT: 0804-HY-13600-01Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13600-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Clobetasol propionate is a potent and selective CYP3A5 inhibitor with an IC50 of 0.206 μM. Clobetasol propionate has no inhibiting on CYP3A4 or other major CYPs. Clobetasol propionate is a corticosteroid and has the potential for psoriasis and other dermatoses research[1][2][3].
CAS Number
25122-46-7
UNSPSC
12352211
Hazard Statement
H360, H373
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/Clobetasol-propionate.html
Purity
99.72
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C[C@@]12[C@](C(CCl)=O)(OC(CC)=O)[C@@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O
Molecular Formula
C25H32ClFO5
Molecular Weight
466.97
Precautions
H360, H373
References & Citations
[1]William C Wright, et al. Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5. J Med Chem. 2020 Feb 13;63 (3) :1415-1433.|[2]Steven R Feldman, et al. Topical clobetasol propionate in the treatment of psoriasis: a review of newer formulations. Am J Clin Dermatol. 2009;10 (6) :397-406.|[3]M Zeigler, et al. Anti-CD11a ameliorates disease in the human psoriatic skin-SCID mouse transplant model: comparison of antibody to CD11a with Cyclosporin A and clobetasol propionate. Lab Invest. 2001 Sep;81 (9) :1253-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CYP3

Related Products

CatalogName
HY-W744187-01Clobetasol 17-Propionate-d5
HY-W749404-01Clobetasone 17-Propionate
HY-125561Josamycin propionate
HY-W011180-01Vitamin A Propionate
HY-B0878-01Halobetasol propionate
HY-156074Erythromycin propionate
HY-W013128Cholesteryl propionate
HY-137173Laidlomycin propionate
HY-137920-01Salvinorin A propionate
HY-41616-01Methoxymethyl propionate

Alternative Products

CatalogName
B1915-50Clobetasol propionate

Popular Products