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WRN (N) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210402Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18210402Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to WRN.WRN (Werner syndrome ATP-dependent helicase) is a magnesium and ATP-dependent DNAhelicase.WRN also has the 3 to 5 exonuclease activity towards double-stranded DNA with 5-overhang, but not single-stranded DNA or blunt-ended double stranded DNA. WRN plays animportant role in the dissociation of joint DNA molecules and the formation of DNA replication focalcenters. Defects in WRN causes Werner syndrome.
Product Name Alternative
Anti-WRN antibody, anti-RECQ3 antibody, anti-RECQL2 antibody
UniProt
Q14191
Reactivity
Human
Immunogen
N-terminal region of human WRN
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Epigenetics & Chromatin
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
162
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · Q14191

Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

WRN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14191
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
WRN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A1KYY9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-bindingZinc

Cellular component

ChromosomeNucleus

Disease

Disease variant

Biological process

DNA damageDNA repair

Molecular function

DNA-bindingExonucleaseHelicaseHydrolaseIsomeraseMultifunctional enzymeNuclease

Domain

Repeat

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