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CHEK1 (C) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210360Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18210360Size:100 µL
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Description
Rabbit polyclonal to CHEK1.Serine/threonine-protein kinase Chk1 (CHEK1) belongs to the CAMK Ser/Thr protein kinase family.CHEK1 is required for checkpoint mediated cell cycle arrest in response to DNA damage or thepresence of unreplicated DNA. CHEK1 also acts to integrate signals from A and ATR, two cellcycle proteins involved in DNA damage responses, that also associate with chromatin in meioticprophase I. Phosphorylation of CDC25A protein phosphatase by CHEK1 is required for cells to delaycell cycle progression in response to double-strand DNA breaks.
Product Name Alternative
Anti-CHEK1 antibody, anti-Serine antibody, anti-threonineprotein kinase Chk1 antibody, anti-CHK1 antibody, anti-CHK1 checkpoint homolog antibody, anti-Cell cycle checkpoint kinase antibody, anti-Checkpoint kinase1 antibody
UniProt
O14757
Reactivity
Human
Immunogen
C-terminal region of human CHEK1
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Epigenetics & Chromatin
Dilution
WB:1:500-1:1000
Purity
Affinity purification
Molecular Weight
54
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · O14757

Serine/threonine-protein kinase Chk1

CHK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14757
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CHEK1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
A8K934, B4DDD0, B4DSK3, B5BTY6, F5H7S4, H2BI51
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleDNA damageDNA repair

Cellular component

ChromosomeCytoplasmCytoskeletonNucleus

Disease

Disease variant

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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