Products for Research Use Only

MDM2 (M) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210354Size: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR18210354Size:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Rabbit polyclonal to MDM2.E3 ubiquitin-protein ligase MDM2 is a target gene of the tumor suppressor p53. MDM2 is a nuclearphosphoprotein that binds and inhibits the transcriptional activity of p53 as part of an autoregulatorynegative feedback loop. Overexpression of MDM2 results in excessive inactivation of p53, diminishingits tumor suppressor function. MDM2 has E3 ubiquitin ligase activity, which targets p53 forproteasomal degradation. MDM2 also affects the cell cycle, apoptosis and tumorigenesis throughinteractions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40different alternatively spliced transcript variants of MDM2 have been isolated from both tumor andnormal tissues.
Product Name Alternative
Anti-MDM2 antibody, anti-E3 ubiquitinprotein ligase MDM2 antibody, anti-Double minute 2 protein antibody, anti-Hdm2 antibody, anti-Oncoprotein Mdm2 antibody, anti-p53binding protein Mdm2 antibody
UniProt
Q00987
Reactivity
Human
Immunogen
Middle region of human MDM2
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cell Biology
Dilution
WB:1:1000-1:3000
Purity
Affinity purification
Molecular Weight
55
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3