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IKKA (C) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210340Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18210340Size:100 µL
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Description
Rabbit polyclonal to IKKA.Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKKA) belongs to the protein kinasesuperfamily. IKKA is a serine kinase that plays an essential role in the NF-kappa-B signaling pathway, which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNAdamages or other cellular stresses. IKKA acts as part of the canonical IKK complex in theconventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B onserine residues. These modifications allow polyubiquitination of the inhibitors and subsequentdegradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus andactivates the transcription of hundreds of genes involved in immune response, growth control, orprotection against apoptosis. In addition, IKKA plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation.
Product Name Alternative
Anti-IKKA antibody, anti-Inhibitor of nuclear factor kappaB kinase subunit alpha antibody, anti-IkappaB kinase alpha antibody, anti-IKKA antibody, anti-IKKalpha antibody, anti- IkBKA antibody, anti-IkappaB kinase antibody, anti-Conserved helixloophelix ubiquitous kinase antibody, anti-IkappaB kinase 1 antibody, anti-IKK1 antibody, anti- Nuclear factor NFkappaB inhibitor kinase alpha antibody, anti-NFKBIKA antibody, anti-Transcription factor 16 antibody, anti-TCF16 antibody, anti-TCF16 antibody
UniProt
O15111
Reactivity
Human, Mouse
Immunogen
C-terminal region of human IKKA
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Signal Transduction
Dilution
WB:1:500-1:2000
Purity
Affinity purification
Molecular Weight
85
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · O15111

Inhibitor of nuclear factor kappa-B kinase subunit alpha

IKKA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15111
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CHUK
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
I-kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase
EC number
2.7.11.10
Processing
—
Secondary accessions
O14666, Q13132, Q5W0I4, Q92467
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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