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TOPORS (C) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210320Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18210320Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to TOPORS.TOPORS functions as an E3 ubiquitin-protein ligase and an E3 SUMO1-protein ligase. It is a probabletumor suppressor involved in cell growth, cell proliferation and apoptosis. TOPORS regulatesp53/TP53 stability through ubiquitin-dependent degradation. It may regulate chromatin modificationthrough sumoylation of several chromatin modification-associated proteins. It may be involved in DNAdamage-induced cell death through IKBKE sumoylation. Defects in TOPORS are the cause of retinitispigmentosa type 31 P31) .
Product Name Alternative
Anti-TOPORS antibody, anti-E3 ubiquitinprotein ligase Topors antibody, anti-SUMO1protein E3 ligase Topors antibody, anti-Topoisomerase Ibinding RING finger protein antibody, anti-Topoisomerase Ibinding arginine antibody, anti-serinerich protein antibody, anti-Tumor suppressor p53binding protein 3 antibody, anti-p53binding protein 3 antibody, anti-p53BP3 antibody, anti-LUN antibody
UniProt
Q9NS56
Reactivity
Human
Immunogen
C-terminal region of human TOPORS
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cancer, DNA Damage, Epigenetics
Dilution
WB:1:500-1:1000
Purity
Affinity purification
Molecular Weight
119
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · Q9NS56

E3 ubiquitin-protein ligase Topors

TOPRS_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NS56
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TOPORS
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
O43273, Q6P987, Q9NS55, Q9UNR9
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

DNA damageUbl conjugation pathway

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Technical term

Proteomics identificationReference proteome

Disease

Retinitis pigmentosa

Molecular function

Transferase

Domain

Zinc-finger

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