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SSK1

CAT: 0804-HY-138936-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138936-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SSK1, a senescence-specific killing compound, is a β-galactosidase-targeted proagent attenuates inflammation. SSK1 is activated by lysosomal β-galactosidase and selectively killed senescent cells through the activation of p38 MAPK and induction of apoptosis[1].
CAS Number
2629250-69-5
UNSPSC
12352005
Target
Apoptosis; p38 MAPK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ssk1.html
Purity
99.75
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(O[C@H]([C@H]([C@H]1OC(C)=O)OC(C)=O)[C@@H](O[C@@H]1COC(C)=O)OC(C=CC(COC(NC(C=CN2[C@](C(F)([C@@H]3O)F)([H])O[C@@H]3CO)=NC2=O)=O)=C4)=C4[N+]([O-])=O)=O
Molecular Formula
C31H34F2N4O18
Molecular Weight
788.61
References & Citations
[1]Yusheng Cai, et al. Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice. Cell Res. 2020 Jul;30 (7) :574-589.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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