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TDG (C) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210293Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18210293Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to TDG.G/T mismatch-specific thymine DNA glycosylase (TDG) belongs to the TDG/mug DNA glycosylasefamily. TDG removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bondbetween the sugar-phosphate backbone of DNA and the mispaired thymine. TDG also removesthymine from C/T and T/T mispairings with lower activity. In addition, TDG can remove uracil and 5-bromouracil from mispairings with guanine. TDG plays a central role in cellular defense againstgenetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine.
Product Name Alternative
Anti-TDG antibody, anti-G antibody, anti-T mismatchspecific thymine DNA glycosylase antibody, anti-ThymineDNA glycosylase antibody
UniProt
Q13569
Reactivity
Human, Mouse
Immunogen
C-terminal region of human TDG
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Epigenetics & Chromatin
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
46
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · Q13569

G/T mismatch-specific thymine DNA glycosylase

TDG_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13569
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TDG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.2.2.29
Processing
—
Secondary accessions
Q8IUZ6, Q8IZM3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorChromatin regulatorHydrolase

Biological process

DNA damageDNA repairTranscriptionTranscription regulation

PTM

Isopeptide bondUbl conjugation

Cellular component

Nucleus

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