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SMARCB1 (N) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210130Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18210130Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to SMARCB1.SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) is a nuclear protein and a core component of the BAF (hSWI/SNF) complex. This ATPdependentchromatin-remodeling complex plays important roles in cell proliferation and differentiation, cellular antiviral activities and inhibition of tumor formation. The BAF (hSWI/SNF) complex relievesrepressive chromatin structures, allowing the transcriptional machinery to access its targets moreeffectively. SMARCB1 may also bind to and enhance the DNA joining activity of HIV-1 integrase.SMARCB1 has been implicated as a tumor suppressor, and mutations in it have been associated withmalignant rhabdoid tumors.
Product Name Alternative
Anti-SMARCB1 antibody, anti-SWI antibody, anti-SNFrelated matrixassociated actindependent regulator of chromatin subfamily B member 1 antibody, anti- BRG1associated factor 47 antibody, anti-BAF47 antibody, anti-Integrase interactor 1 protein antibody, anti-SNF5 homolog antibody, anti-hSNF5 antibody, anti-BAF47 antibody, anti- INI1 antibody, anti-SNF5L1 antibody
UniProt
Q12824
Reactivity
Human
Immunogen
N-terminal region of human SMARCB1
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Epigenetics & Chromatin
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
44
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · Q12824

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

SNF5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q12824
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SMARCB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O75784, O95474, Q17S11, Q38GA1, Q76N08, Q9UBH2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorChromatin regulatorDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleHost-virus interactionNeurogenesisTranscriptionTranscription regulation

Disease

Disease variantHypotrichosisIntellectual disabilityTumor suppressor

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Cellular component

Nucleus

Domain

Repeat

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