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PARP (N) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18209988Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18209988Size:100 µL
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Description
Rabbit polyclonal to PARP.Poly [ADP-ribose] polymerase 1 (PARP) is involved in the base excision repair (BER) pathway bycatalyzing the poly (ADP-ribosyl) ation of a limited number of acceptor proteins involved in chromatinarchitecture and in DNA metabolism. This modification follows DNA damages and appears as anobligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARPpositively regulates the transcription of MTUS1 and negatively regulates the transcription ofMTUS2/TIP150.
Product Name Alternative
Anti-PARP antibody, anti-ADPRT antibody, anti-PPOL antibody, anti-Poly [ADPribose] polymerase 1 antibody, anti-PARP1 antibody, anti-NAD (+) ADPribosyltransferase 1 antibody, anti-ADPRT 1 antibody, anti-Poly[ADPribose] synthase 1 antibody
UniProt
P09874
Reactivity
Human
Immunogen
N-terminal region of human PARP
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cancer, DNA Damage, Epigenetics
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
113
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · P09874

Poly [ADP-ribose] polymerase 1

PARP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09874
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PARP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PARP-1
EC number
2.4.2.30
Processing
—
Secondary accessions
B1ANJ4, Q8IUZ9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationADP-ribosylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

Allosteric enzymeDNA-bindingGlycosyltransferaseNucleotidyltransferaseTransferase

Biological process

ApoptosisDNA damageDNA repairImmunityInnate immunityTranscriptionTranscription regulation

Cellular component

ChromosomeCytoplasmNucleus

Ligand

Metal-bindingNADZinc

Domain

RepeatZinc-finger

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