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SHH (C1) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18209653Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18209653Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to SHH.Sonic hedgehog (SHH) protein is instrumental in the development of all known animals. In theembryo, it is the key signal in patterning of the ventral neural tube, the anterior-posterior limb axis, andthe ventral somites. In the adult it controls stem cell proliferation. It binds to the patched (PTC) receptor, which functions in association with smoothened (SMO) to activate the transcription of genes.Disruption in SHH signaling during development either through defects in the protein, or maternalteratogen consumption can lead to developmental disorders such as holoprosencephaly (HPE) .Abberant activation of the SHH signaling pathway is associated with several types of cancer.
Product Name Alternative
Anti-SHH antibody, anti-HHG1 antibody, anti-HLP3 antibody, anti-HPE3 antibody, anti-MCOPCB5 antibody, anti-SMMCI antibody, anti-TPT antibody, anti-TPTPS antibody
UniProt
Q15465
Reactivity
Human, Mouse
Immunogen
C-terminal region of human SHH
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cell Biology
Purity
Affinity purification
Molecular Weight
50
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · Q15465

Sonic hedgehog protein

SHH_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15465
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SHH
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SHH
EC number
3.1.-.-
Processing
Precursor
Secondary accessions
A4D247, Q75MC9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Autocatalytic cleavageGlycoproteinLipoproteinPalmitate

Ligand

CalciumMetal-bindingZinc

Cellular component

Cell membraneEndoplasmic reticulumGolgi apparatusMembraneSecreted

Molecular function

Developmental proteinHydrolaseProteaseTransferase

Disease

Disease variantHoloprosencephalyMicrophthalmia

Domain

Signal

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