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FLT3 (C) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18209618Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18209618Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to FLT3.FMS-related tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that regulates hematopoiesis.Upon ligand binding, the receptor is activated inducing a homodimer formation in the plasmamembrane leading to autophosphorylation of the receptor. Activated FLT3 can also phosphorylateand activate multiple cytoplasmic effector molecules in pathways implicated in apoptosis, proliferationand differentiation of hematopoietic cells in bone marrow. Mutations that result in constitutiveactivation of this receptor are associated with acute myeloid leukemia and acute lymphoblasticleukemia.
Product Name Alternative
Anti-FLT3 antibody, anti-B230315G04 antibody, anti-CD135 antibody, anti-Flk2 antibody, anti-Flk2 antibody, anti-Flt3 antibody, anti-Ly72 antibody, anti-MGC124377 antibody, anti-MGC124378 antibody, anti-wmfl antibody
UniProt
Q00342
Reactivity
Human, Mouse
Immunogen
C-terminal region of mouse FLT3
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cell Biology
Dilution
WB:1:1000-1:5000
Purity
Affinity purification
Molecular Weight
113
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.01% NaN3

UniProtKB · Q00342

Receptor-type tyrosine-protein kinase FLT3

FLT3_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q00342
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Flt3
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
—
Protein keywords

Ligand

ATP-bindingNucleotide-binding

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Cellular component

Endoplasmic reticulumMembrane

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

Disease

Proto-oncogene

Technical term

Reference proteome

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