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BTS

CAT: 0804-HY-16690-03Size: 5 gDry Ice: NoHazardous: No
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CAT#:0804-HY-16690-03Size:5 g
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Description
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC50s of ~5 μM for actin- and Ca2+-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers[1][2].
CAS Number
1576-37-0
Product Name Alternative
N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Myosin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/BTS.html
Purity
99.74
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(NCC1=CC=CC=C1)(C2=CC=C(C)C=C2)=O
Molecular Formula
C14H15NO2S
Molecular Weight
261.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Cheung A, et al. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol. 2002 Jan;4 (1) :83-8.|[2]Shaw MA, et, al. Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry. 2003 May 27;42 (20) :6128-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

p-Toluenesulfonamide, N-benzyl-

4-methyl-N-(phenylmethyl)benzenesulfonamide is a sulfonamide.

CAS Number1576-37-0
PubChem CID95801
IUPAC NameN-benzyl-4-methylbenzenesulfonamide
Molecular FormulaC14H15NO2S
Molecular Weight261.34
XLogP2.7
Topological Polar Surface Area54.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count18
Formal Charge0
Complexity333
SMILES
CC1=CC=C(C=C1)S(=O)(=O)NCC2=CC=CC=C2
InChI
InChI=1S/C14H15NO2S/c1-12-7-9-14(10-8-12)18(16,17)15-11-13-5-3-2-4-6-13/h2-10,15H,11H2,1H3
InChIKey
WTHKAJZQYNKTCJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of p-Toluenesulfonamide, N-benzyl-
CAS: 1576-37-0
CID: 95801
Formula: C14H15NO2S
MW: 261.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight261.34
XLogP32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass261.08234989
Monoisotopic Mass261.08234989
Topological Polar Surface Area54.6 Ų
Heavy Atom Count18
Formal Charge0
Complexity333
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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