IFNAR1, Rhesus Macaque (HEK293)
CAT:
804-HY-P76406-01
Size:
10 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
IFNAR1, Rhesus Macaque (HEK293)
- UNSPSC Description: IFNAR1, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFNAR1 forms the heterodimeric receptor with IFNAR2. IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2)[1][2]. Upon activation by these IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2[3]. IFNAR1 Protein, Rhesus Macaque (HEK293) is a recombinant rhesus macaque IFNAR1 (M1-K437) without any tag, which is produced in HEK293 cells.
- Type: Recombinant Proteins
- Assay Protocol: https://www.medchemexpress.com/cytokines/ifnar1-protein-rhesus-macaque-hek293.html
- Purity: 96.00
- Smiles: AGGKNLKSPQ KVEVDVIDDN FILRWNRSEE SVGNVTFSFD YQKPEMDNWI KLPGCQNMTS TKCNFSSLKL NIYDEIKLRI RAEKENTSSW CEVDSFTPFR KAQIGPPEVH LEAEDKAIVI YISPPGTEDS VMWALDRSSF TYSLVIWKNS SSVEERIENI YSRHKISKLS PETTYCLKVK AALLTSRKIG VYGPVHCIKT TVENELPPPE NIEVIVQNQN YVLKWDYTYA NMTFQVQWLH AFLKRKPGNH LYKWKQIPDC KNVTTTQCVF PQNTFQKGIY LLRVQASDGN NTSFWSEEIK FDTEIQASLL PPVFNIRSLS DSLHISIGAP KWSENKPVIQ DYPLIYEILF WENTSKAERK IIKKKTDVTI PNLKPLTVYC VKARAHSMDE KLNKSSVFSD VVCEETKSGN TSK
- Molecular Weight: Approximately 68-100 kDa due to the glycosylation.
- References & Citations: [1]Zanin N, et al. Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads. Front Immunol. 2021 Jan 20;11:615603.|[2]Shemesh M, et al. IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs. Sci Signal. 2021 Nov 23;14(710):eabe4627.|[3]Jun Zou, et al. Chapter 7 - Antiviral Immunity: Origin and Evolution in Vertebrates. The Evolution of the Immune System. 2016,Pages 173-204.|[4]Pogue SL, et al. The receptor for type I IFNs is highly expressed on peripheral blood B cells and monocytes and mediates a distinct profile of differentiation and activation of these cells. J Interferon Cytokine Res. 2004 Feb;24(2):131-9.
- Shipping Conditions: Blue Ice
- Storage Conditions: Stored at -20°C for 2 years