Products for Research Use Only
RegisterLogin

CZC-54252

CAT: 0804-HY-B0792-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0792-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. CZC-54252 attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of ~1 nM. CZC-54252 has a neuroprotective activity[1].
CAS Number
1191911-27-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
LRRK2
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CZC-54252.html
Purity
98.05
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O
Molecular Formula
C22H25ClN6O4S
Molecular Weight
504.99
Precautions
H302, H315, H319, H335
References & Citations
[1]Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6 (10) :1021-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-15800A-01CZC-25146
HY-111138-01CZC-8004
HY-15800CZC-25146 (hydrochloride)
HY-10213-01SNX-5422
HY-10213ASNX-5422 (mesylate)

Alternative Products

CatalogName
445446-01CZC 54252
407148CZC-54252
B5633-25CZC 54252 hydrochloride
T39202-01CZC-54252 hydrochloride
556103CZC-54252 HCl

Popular Products