ZINC110492

CAT: 0804-HY-Q51222Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-Q51222Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

ZINC110492 is a selective ligand of CS-ΔEx4 (a splicing isoform of citrate synthase (CS) ) . ZINC110492 does not bind to CS full-length (CS-FL) . ZINC110492 inhibits colorectal cancer (CRC) cell growth in cells overexpressing CS-ΔEx4 with an IC50 of 7.840 µM. ZINC110492 significantly decreases both citrate and 2-hydroxyglutarate (2-HG) levels in the CS-ΔEx4-overexpressing SW1116 cells[1].

CAS Number

100264-64-0

UNSPSC

12352005

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/6-3-nitrophenyl-5h-dibenzo-c-e-azepine-5-7-6h-dione.html

Purity

90.0

Smiles

O=C1C2=C(C3=C(C(N1C4=CC([N+]([O-])=O)=CC=C4)=O)C=CC=C3)C=CC=C2

Molecular Formula

C20H12N2O4

Molecular Weight

344.32

References & Citations

[1]Cheung JCT, et al. A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression. Cancer Res. 2025 Sep 3.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

ZINC110492

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