7-Methoxy-1-tetralone

7-Methoxy-1-tetralone

• CAS Number: 6836-19-7
• UNSPSC Description: 7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index[1].
• Target Antigen: Akt; Apoptosis; c-Met/HGFR; MMP; NF-κB
• Type: Natural Products
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/7-methoxy-1-tetralone.html
• Purity: 99.93
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(CCC1)C2=C1C=CC(OC)=C2
• Molecular Weight: 176.215
• References & Citations: [1]Wen Y, et al. 7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-κB, MMP2, and MMP9 Expression. Front Oncol. 2020 Feb 7;10:58.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported