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Carbenoxolone

CAT: 0804-HY-B1588Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1588Size:1 Each
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Description
Carbenoxolone, a semi-synthetic derivative of glycyrrhetinic acid, has previously been used for the management of dyspepsia and peptic ulcer because of its anti-inflammatory properties[3]. Carbenoxolone, a general hemichannel and gap junction inhibitor, has the therapeutic potential of carbenoxolone in the treatment of chronic liver disease[2]. Carbenoxolone is a suitable candidate for the inhibition of Aβ42 aggregation and the therapeutic potential of Cbx against AD[1]. Carbenoxolone is small molecule Pannexin1 (Panx1, is an ATP release channel) inhibitor, attenuate Panx1 channel activity through modulation of the first extracellular loop[4]. Carbenoxolone is an 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor[5]. Carbenoxolone has antiviral activity against DENV infection targeting the virus itself[6].
CAS Number
5697-56-3
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Amyloid-β; HIV
Type
Natural Products
Related Pathways
Anti-infection; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/carbenoxolone.html
Solubility
10 mM in DMSO
Smiles
CC(C)([C@]1([H])CC[C@@]([C@@]2(CC[C@]3(CC[C@](C(O)=O)(C[C@]3(C2=C4)[H])C)C)C)5C)[C@@H](OC(CCC(O)=O)=O)CC[C@]1(C)[C@@]5([H])C4=O
Molecular Formula
C34H50O7
Molecular Weight
570.76
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Sharma S, et al. Inhibition of Alzheimer's amyloid-beta aggregation in-vitro by carbenoxolone:Insight into mechanism of action. Neurochem Int. 2017 Sep;108:481-493.|[2]Crespo Yanguas S, et al. TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice. Int J Mol Sci. 2018 Mar 12;19 (3) . pii: E817.|[3]Hirata K, et al. Formulation of carbenoxolone for delivery to the skin. Int J Pharm. 2013 May 20;448 (2) :360-5.|[4]Michalski K, et al. Carbenoxolone inhibits Pannexin1 channels through interactions in the first extracellular loop. J Gen Physiol. 2016 Feb;147 (2) :165-74.|[5]Kim J, et al. Protective effect of carbenoxolone on ER stress-induced cell death in hypothalamic neurons. Biochem Biophys Res Commun. 2015 Dec 25;468 (4) :793-9.|[6]Pu J, et al. Antiviral activity of Carbenoxolone disodium against dengue virus infection. J Med Virol. 2017 Apr;89 (4) :571-581
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
Launched

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