KOTX1

CAT: 0804-HY-164781-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-164781-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

KOTX1 is an orally active and selective ALDH1A3 inhibitor. KOTX1 improves glucose tolerance, insulin secretion and blood sugar levels in diabetic mouse models[1].

CAS Number

1788963-83-6

Product Name Alternative

MBE1

UNSPSC

12352005

Target

Aldehyde Dehydrogenase (ALDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/kotx1.html

Purity

98.94

Solubility

DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

O=C(C1=C(CC)C=NC=C1)NC2=C(F)C=C(NC(CC3)=O)C3=C2

Molecular Formula

C17H16FN3O2

Molecular Weight

313.33

References & Citations

[1]Son J, et al. Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure. Nat Commun. 2023 Feb 2;14 (1) :558.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ALDH1

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Catalog	Name
T203191-01	KOTX1

KOTX1

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