PARP7-IN-16 (free base)

PARP7-IN-16 (free base)

• CAS Number: 2136325-05-6
• UNSPSC Description: PARP7-IN-16 free base is the free base form of PARP7-IN-16 (HY-156419). PARP7-IN-16 free base is a selective and orally active inhibitor of PARP-1/2/7, with IC50s of 0.94, 0.87 and 0.21 nM, respectively. PARP7-IN-16 can be used for the research of breast cancer and prostate cancer[1].
• Target Antigen: PARP
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/parp7-in-16-free-base.html
• Solubility: DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(NC1=O)C2=CC=CC=C2N1CC3=CC=C(C(C(N4CCN(C(C4)=O)C(CC)CC)=O)=C3)F
• Molecular Weight: 466.50
• References & Citations: [1]Zhou J, et, al. Discovery of Quinazoline-2,4(1 H,3 H)-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J Med Chem. 2023 Oct 26;66(20):14095-14115.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported