ITCH (N1) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210259Size: 100 µLDry Ice: NoHazardous: No

1 / 1

CAT#:0013-GTR18210259Size:100 µL

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Rabbit polyclonal to ITCH.E3 ubiquitin-protein ligase Itchy homolog (ITCH) acts as an E3 ubiquitin-protein ligase. ITCHubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway. It isinvolved in the negative regulation of MAVS-dependent cellular antiviral responses. ITCH is involvedin the regulation of apoptosis and reactive oxygen species levels through the ubiquitination andproteasomal degradation of TXNIP. It mediates the antiapoptotic activity of epidermal growth factorthrough the ubiquitination and proteasomal degradation of p15 BID. Defects in ITCH are the cause ofsyndromic multisystem autoimmune disease (SMAD) .

Product Name Alternative

Anti-ITCH antibody, anti-E3 ubiquitinprotein ligase Itchy homolog antibody, anti-Atrophin1interacting protein 4 antibody, anti-AIP4 antibody, anti-NFE2associated polypeptide 1 antibody, anti-NAPP1 antibody

UniProt

Q96J02

Reactivity

Human

Immunogen

N-terminal region of human ITCH

Clonality

Polyclonal

Conjugation

Unconjugated

Field of Research

Infectious Disease & Virology

Dilution

WB:1:500-1:1000

Purity

Affinity purification

Molecular Weight

103

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Tested Applications

Host or Source

Rabbit

Preservative

0.01% NaN3

UniProtKB · Q96J02

E3 ubiquitin-protein ligase Itchy homolog

ITCH_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q96J02
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ITCH
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: Itch
EC number: 2.3.2.26
Processing: —
Secondary accessions: A6NEW4, B4E234, E1P5P3, F5H217, O43584, Q5QP37, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseApoptosisHost-virus interactionImmunityInnate immunityUbl conjugation pathway

Cellular component

Cell membraneCytoplasmEndosomeMembraneNucleus

Domain

Repeat

Molecular function

Transferase

Related Products

Catalog	Name
GTR17869690	ITCH Rabbit Polyclonal Antibody
GTR18080760-01	ITCH Rabbit Polyclonal Antibody
GTR18080759-01	ITCH Rabbit Polyclonal Antibody
GTR18112993-01	ITCH Rabbit Polyclonal Antibody
GTR18682851-01	ITCH Rabbit Polyclonal Antibody
GTR18379024	ITCH Rabbit Polyclonal Antibody (Biotin)
GTR17689126	ITCH/AIP4 Rabbit Polyclonal Antibody
GTR17710744-01	ITCH/AIP4 Rabbit Polyclonal Antibody
GTR18296453	ITCH polyclonal antibody
GTR18379013	ITCH Rabbit Polyclonal Antibody (FITC)

Alternative Products

Catalog	Name
E28PT2124	Hel-N1 Rabbit Polyclonal Antibody
NB300-114	Rabbit Polyclonal NMDA receptor N1 Antibody
JOT-AP03938-01	Hel-N1 Polyclonal Antibody
PAV7859	Rabbit Anti-Hel-N1/ELAVL2 Polyclonal Antibody
PA86131HU-01	Rabbit Anti-Human Hel-N1 Polyclonal Antibody
TRV-002531-01	Polyclonal Antibody to Carboxypeptidase N1 (CPN1)
BS2299-01	Hel-N1 (S27) polyclonal antibody
BS1966-01	Hel-N1 (N86) polyclonal antibody
CAU31766-01	Selenoprotein N1 (SEPN1) Polyclonal Antibody
VD3N425	Rabbit Anti-Mouse Carboxypeptidase N1 (CPN1) Polyclonal Antibody