LXRA (M) Antibody, Rabbit Polyclonal

CAT: 0013-GTR18210123Size: 100 µLDry Ice: NoHazardous: No

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CAT#:0013-GTR18210123Size:100 µL

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Description

Rabbit polyclonal to LXRA.Liver X receptor alpha (LXRA) belongs to the nuclear hormone receptor family, NR1 subfamily. LXRAis an orphan receptor. LXRA can form a heterodimer with RXR, which shifts RXR from a silent DNAbindingpartner to an active ligand-binding subunit in mediating retinoid responses through targetgenes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats oftwo similar hexanuclotide half-sites spaced by four nucleotides. LXRA plays an important role in theregulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependentubiquitination of LDLR, VLDLR and LRP8.

Product Name Alternative

Anti-LXRA antibody, anti-Oxysterols receptor LXRalpha antibody, anti-Liver X receptor alpha antibody, anti-Nuclear receptor subfamily 1 group H member 3 antibody, anti-NR1H3 antibody

UniProt

Q13133

Reactivity

Human, Mouse

Immunogen

Middle region of human LXRA

Clonality

Polyclonal

Conjugation

Unconjugated

Field of Research

Epigenetics

Dilution

WB:1:1000-1:5000

Purity

Affinity purification

Molecular Weight

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Tested Applications

Host or Source

Rabbit

Preservative

0.01% NaN3

UniProtKB · Q13133

Oxysterols receptor LXR-alpha

NR1H3_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q13133
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: NR1H3
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A8K3J9, D3DQR1, Q8IW13, Q96H87

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingReceptor

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Ligand

Metal-bindingZinc

Biological process

TranscriptionTranscription regulation

PTM

Ubl conjugation

Domain

Zinc-finger

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