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VU0546110

CAT: 0804-HY-164911-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164911-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3, with IC50s of 1.287 μM (SLO3) and 59.80 μM (SLO1) in HEK293 cells, respectively. VU0546110 blocks heterologous SLO3 currents and endogenous K+ currents in human sperm. VU0546110 halts sperm hyperpolarization, induced acrosome reaction, and hyper-activated motility. VU0546110 has contraceptive potential[1].
CAS Number
1421523-00-3
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/vu0546110.html
Purity
98.47
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CC1=CC=C(S(=O)(C(C)C)=O)C=C1)N2CCC(CC2)CSC3=CC=C(C=C3)OC
Molecular Formula
C24H31NO4S2
Molecular Weight
461.64
References & Citations
[1]Lyon M, et al. A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function. Proceedings of the National Academy of Sciences of the United States of America. 2023, 120 (4), e2212338120.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
AR-V07089-01VU0546110

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