Recombinant Human BLAME/SLAMF8 Protein(Fc Tag)

Recombinant Human BLAME/SLAMF8 Protein(Fc Tag)

• Background: The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain , SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules , a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors , in association with SAP family adaptors , have crucial roles during normal immune reactions in innate and adaptive immune cells.Mouse SLAM family member 8 , also known as B-lymphocyte activator macrophage expressed , BCM-like membrane protein , SLAMF8 and BLAME , is a single-pass type I membrane protein. It contains one Ig-like C2-type (immunoglobulin-like) domain. SLAMF8 / BLAME is expressed in lymph node , spleen , thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.
• Abbreviation: BLAME/SLAMF8
• Synonyms: SLAM family member, SBBI, SLAF, Slamf, BCM-like membrane protein, B-lymphocyte activator macrophage expressed, CD353, SBBI42, SLAF8, SLAM family member 8, BLAME, SLAMF8, BLAME, SBBI42
• CAS Number: 9000-83-3
• UniProt: Q9P0V8
• Accession Number: Q9P0V8
• Host: Mammalian
• Origin Species: Human
• Tag: C-Fc
• Sequence: Ala23-Asp233
• Field of Research: Immunology
• Purity: > 90% as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
• Molecular Weight: 55 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.