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Boceprevir

CAT: 0223-11-075Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0223-11-075Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The antiviral agent boceprevir is a protease inhibitor that covalently and reversibly binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication (Ki = 14nM) by cleaving the virally encoded polyprotein into mature proteins like NS4A, NS4B, NS5A and NS5B. It inhibits the NS3/4A protease in an in vitro HCV replicon system with an EC50 value of 200 nM. Boceprevir has been identified as a potential inhibitor of SARS-CoV-2 responsible for COVID-19. It inhibits SARS-CoV-2 viral replication by targeting the viral main protease Mpro (IC50 = 4.13µM) .
CAS Number
394730-60-0
Type
Chemical
Purity
Greater than or equal to 95% (NMR)
Shipping Conditions
Room Temp
Storage Conditions
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Calculated Molecular Weight
519.7
Other Product Names
Victrelis; EBP 520; SCH 503034
Physical Properties
Lyophilized

Alternative Products

CatalogName
A3261-10Boceprevir

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