Boceprevir

• Background:

  The antiviral agent boceprevir is a protease inhibitor that covalently and reversibly binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication (Ki = 14nM) by cleaving the virally encoded polyprotein into mature proteins like NS4A, NS4B, NS5A and NS5B. It inhibits the NS3/4A protease in an in vitro HCV replicon system with an EC50 value of 200 nM. Boceprevir has been identified as a potential inhibitor of SARS-CoV-2 responsible for COVID-19. It inhibits SARS-CoV-2 viral replication by targeting the viral main protease Mpro (IC50 = 4.13µM) .

• Type:

  Chemical

• Purity:

  Greater than or equal to 95% (NMR)

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

• Calculated Molecular Weight:

  519.7

• Other Product Names:

  Victrelis; EBP 520; SCH 503034

• Physical Properties:

  Lyophilized

• CAS Number:

  394730-60-0