Famotidine

• Background:

  Famotidine is a histamine H2 receptor antagonist. It is selective for H2 over H1 and muscarinic receptors (Kis = 4 and 28 µM, respectively, in bovine cerebral cortex) . Famotidine blocks the action of histamine in the parietal cells, ultimately blocking acid secretion in the stomach. It inhibits histamine-induced acid secretion in isolated canine parietal cells (IC50 = 0.6µM) and suppresses histamine-induced gastric acid secretion in dogs when administered orally and in anesthetized rats when administered intraduodenally (ID50s = 10 and 400µg/kg, respectively) . Famotidine is used to treat ulcers, gastroesophageal reflux disease (GERD) and heartburn and it decreases the risk of gastrointestinal toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs) . Potential inhibitor of the viral enzyme papain-like protease (PLpro), important for SARS-CoV-2 replication and being tested in COVID-19 clinical trials.

• Type:

  Chemical

• Purity:

  Greater than or equal to 98% (HPLC)

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Protect from moisture. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

• Calculated Molecular Weight:

  337.5

• Other Product Names:

  MK-208; YM-11170; Pepcid; N′- (Aminosulfonyl) -3- ([2- (diaminomethyleneamino) -4-thiazolyl]methylthio) propanamidine

• Physical Properties:

  Lyophilized

• CAS Number:

  76824-35-6