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Darunavir . ethanolate

CAT: 0223-10-022Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0223-10-022Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Darunavir ethanolate is a highly potent HIV protease inhibitor (IC50=3-6nM, depending on laboratory HIV-1 strain), an antiretroviral medication used to treat and prevent HIV/AIDS. The ethanolate formulation has some stability advantages compared to the free base Darunavir (Prod. No. AG-CR1-3712) . Darunavir ethanolate is a second generation HIV-1 protease inhibitor that inhibits replication of various laboratory strains and clinical isolates of HIV-1, including those resistant to first generation protease inhibitors. It inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations. Formulations containing darunavir have been used in combination therapy for the treatment of HIV. Shown in a SARS-CoV-2 protease structure model study to potentially bind and inhibit the papain like viral protease (PLVP) of SARS-CoV-2, responsible for COVID-19.
CAS Number
635728-49-3
Type
Chemical
Purity
Greater than or equal to 98% (HPLC)
Shipping Conditions
Room Temp
Storage Conditions
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Calculated Molecular Weight
547.7 . 46.0
Other Product Names
TMC114; TMC41629; UIC-94017; HSDB 7788; Prezista
Physical Properties
Lyophilized

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