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Amastatin . hydrochloride

CAT: 0223-10-016Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0223-10-016Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Slow, tight binding and competitive aminopeptidase (AP) inhibitor. Inhibits cytosolic leucine aminopeptidase, microsomal aminopeptidase M and bacterial leucine aminopeptidase, human serum aminopeptidase A (AP-A), aminopeptidase N (AP-N), tyrosine aminopeptidase, but not aminopeptidase B (AP-B) . Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin or thermolysin. Inhibits completely the Suc-Ala-Ala-Pro-Leu-pNA amidolytic enzyme. Slightly inhibits the formation of angiotensin III (Ang III) from Angiotensin II through AP-A, but significantly increases the potency of angiotensin III and [des-Asp1]-angiotensin I. Moderate inhibitor of mitochondrial intermediate peptidase (MIP) . Weak inhibitor of simian immunodeficiency virus protease (SIV-PR) . ANPEP (aminopeptidase N) is a host receptor targeted by porcine epidemic diarrhoea virus, human coronavirus 229E, feline coronavirus, canine coronavirus, transmissible gastroenteritis virus and infectious bronchitis virus. These viruses all belong to coronaviridae. ANPEP is therefore investigated as a potential target for SARS-CoV-2 infections.
CAS Number
100938-10-1
Type
Chemical
Purity
Greater than or equal to 98% (HPLC)
Shipping Conditions
Room Temp
Storage Conditions
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Protect from moisture. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Calculated Molecular Weight
474.6 . 36.5
Other Product Names
[ (2S,3R) -3-Amino-2-hydroxy-5-methyl-hexanoyl]-Val-Val-Asp-OH . HCl
Physical Properties
Lyophilized

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