FITC Conjugated Bcl-2 Recombinant Rabbit Monoclonal Antibody [JF104-8]

FITC Conjugated Bcl-2 Recombinant Rabbit Monoclonal Antibody [JF104-8]

• Description: Bcl-2 is one among many key regulators of apoptosis, which are essential for proper development, tissue homeostasis, and protection against foreign pathogens. Human Bcl-2 is an anti-apoptotic, membrane-associated oncoprotein that can promote cell survival through protein-protein interactions with other Bcl-2 related family members, such as the death suppressors Bcl-xL, Mcl-1, Bcl-w, and A1 or the death agonists Bax, Bak, Bik, Bad, and Bid. The anti-apoptotic function of Bcl-2 can also be regulated through proteolytic processing and phospho-rylation. Bcl-2 may promote cell survival by interfering with the activation of the cytochrome c/Apaf-1 pathway through stabilization of the mitochondrial membrane. Mutations in the Bcl-2 gene can contribute to cancers where normal physiological cell death mechanisms are compromised by deregulation of the anti-apoptotic influence of Bcl-2.
• Product Name Alternative: Apoptosis regulator Bcl 2 antibody Apoptosis regulator Bcl-2 antibody Apoptosis regulator Bcl2 antibody AW986256 antibody B cell CLL/lymphoma 2 antibody B cell leukemia/lymphoma 2 antibody Bcl-2 antibody Bcl2 antibody BCL2_HUMAN antibody C430015F12Rik antibody D630044D05Rik antibody D830018M01Rik antibody Leukemia/lymphoma, B-cell, 2 antibody Oncogene B-cell leukemia 2 antibody PPP1R50 antibody Protein phosphatase 1, regulatory subunit 50 antibody Bcl 2 antibody
• Abbreviation: BCL2
• CAS Number: 9000-83-3
• Swiss Prot: P10415 Human, P10417 Mouse
• Cellular Locus: Mitochondrion outer membrane, Nucleus membrane, Endoplasmic reticulum membrane, Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Recombinant protein within human Bcl-2 aa 1-230.
• Isotype: IgG
• Clone: JF104-8
• Conjugation: FITC-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: FC
• Positive Control: Mouse granulocytes, mouse lymphocytes.
• Dilution: FC: 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: Supplied in phosphate-buffered solution, pH 7.2, containing 0.2% ProClean 950 and BSA.
• Molecular Weight: Predicted band size: 26 kDa
• Storage Conditions: Store at 2°C to 8°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes