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Herbacetin

CAT: 0804-HY-N0240-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0240-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects[1]. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis[2].
CAS Number
527-95-7
UNSPSC
12352005
Hazard Statement
H301
Target
Ornithine decarboxylase (ODC)
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/herbacetin.html
Purity
99.70
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(O)=C(C2=CC=C(O)C=C2)OC3=C(O)C(O)=CC(O)=C13
Molecular Formula
C15H10O7
Molecular Weight
302.24
Precautions
H301
References & Citations
[1]Veeramani C, et al. Herbacetin, a flaxseed flavonoid, ameliorates high percent dietary fat induced insulin resistance and lipid accumulation through the regulation of hepatic lipid metabolizing and lipid-regulating enzymes. Chem Biol Interact. 2018 May 25;288:49-56.|[2]Kim DJ, et al. Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity. Cancer Res. 2016 Mar 1;76 (5) :1146-1157.|[3]Qian J, Li Y, Zhang X, et al. Herbacetin Broadly Blocks the Activities of CYP450s by Different Inhibitory Mechanisms [published online ahead of print, 2021 Jun 11]. Planta Med. 2021;10.1055/a-1502-7131. |[4]Li L, Fan P, Chou H, Li J, Wang K, Li H. Herbacetin suppressed MMP9 mediated angiogenesis of malignant melanoma through blocking EGFR-ERK/AKT signaling pathway. Biochimie. 2019;162:198-207.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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