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UBE2M Recombinant Protein

CAT: 0223-92-178Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-92-178Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
UBE2M is a member of the E2 ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. UBE2M accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. It involved in cell proliferation and is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
CAS Number
9000-83-3
NCBI Gene ID
9040
Swiss Prot
P61081
Accession Number
P61081
Tag
Tag Free
Type
Recombinant Proteins
Source
E. coli
Field of Research
Homeostasis
Buffer
Supplied as a 0.2 um filtered solution of 50mM HEPES, pH 7.5,2mM DTT,150mM NaCl,10%glycerol . It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
20.9 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Ubiquitin conjugating enzyme E2 M
NCBI Organism
Homo sapiens
Other Product Names
NEDD8-conjugating enzyme Ubc12, NEDD8 carrier protein, NEDD8 protein ligase, Ubiquitin-conjugating enzyme E2 M, UBC12, UBE2M
Species
Human
Physical Properties
Liquid

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