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ROR1 Recombinant Protein

CAT: 0223-97-047Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-97-047Size:0.1 mg
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Background
Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1epsilon) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.
CAS Number
9000-83-3
NCBI Gene ID
362550
Accession Number
EDL97819
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
43.5 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Similar to Tyrosine-protein kinase transmembrane receptor ROR1 precursor (Neurotrophic tyrosine kinase, receptor-related 1) (predicted)
NCBI Organism
Rattus norvegicus
Background Reference 01
Masiakowski P., et al., 1992, J. Biol. Chem. 267:26181-26190.
Background Reference 02
Reddy U.R., et al., 1996, Oncogene 13:1555-1559.
Background Reference 03
Greenman C., et al., 2007, Nature 446:153-158.
Other Product Names
ROR1, NTRKR1
Tested Applications
WB
Species
Rat
Physical Properties
Lyophilized

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