SARS-CoV-2 (COVID-19) S1 (D614G) Recombinant Protein

• Background:

  The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS) . The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

• NCBI Gene ID:

  43740568

• Swiss Prot:

  QHD43416.1

• Accession Number:

  QHD43416.1

• Tag:

  C-10 His tag

• Type:

  Recombinant Proteins

• Source:

  Mammalian Cells

• Field of Research:

  Infectious Disease, COVID-19

• Purity:

  Greater than 90% as determined by reducing SDS-PAGE.

• Buffer:

  Supplied as a 0.2 uM filtered solution of PBS, pH 7.4.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Reconstituted protein solution should be store below -20˚ C.

• Calculated Molecular Weight:

  76.6kDa, 100-130kDa

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Surface glycoprotein

• NCBI Organism:

  Severe acute respiratory syndrome coronavirus 2

• Other Product Names:

  S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein

• Species:

  SARS-CoV-2

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3