IGF-I Recombinant Protein

• Background:

  The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.

• NCBI Gene ID:

  3486

• Swiss Prot:

  P05019-3

• Accession Number:

  NP_000589.2

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cancer, Cell Cycle, Growth Factors, Homeostasis, Obesity, Signal Transduction, Stem Cell

• Purity:

  Greater than 98% by SDS-PAGE gel and HPLC analyses.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized IGF-I recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted IGF-I is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing IGF-I recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Insulin-like growth factor binding protein 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  IBP3, BP-53, IBP1, Insulin-like growth factor I, Mechano growth factor, IGF-I

• Species:

  Human

• Protein ID:

  62243068

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3